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Journal of Experimental Medicine A new issue of the JEM is online now. Check out the complete table of contents at the link below:
Journal of Experimental Medicine 's feed: biobytes podcast
biobytes: November 16, 2009
In the November 16th edition of biobytes, Cathleen Carlin (Case Western Reserve University, Cleveland, OH) explains how an adenoviral protein regulates cholesterol trafficking... (more)
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In the November 16th edition of biobytes, Cathleen Carlin (Case Western Reserve University, Cleveland, OH) explains how an adenoviral protein regulates cholesterol trafficking... (more)
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Journal of Experimental Medicine
A team of G protein subunits have opposing agendas during thrombin-induced increases in lung vessel permeability, show Knezevic and colleagues. The findings identify a potential new therapy target for the treatment of acute respiratory distress syndrome (ARDS), which kills tens of thousands of patients in the US every year.
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http://jem.rupress.org/cgi/content/full/
Journal of Experimental Medicine 's feed: Early Release Articles
The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus
The transcription factor Ets1 contributes to the differentiation of CD8 lineage cells in the thymus, but how it does so is not understood. In this study, we demonstrate that Ets1 is requ...ired for the proper termination of CD4 expression during the differentiation of major histocompatability class...
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The transcription factor Ets1 contributes to the differentiation of CD8 lineage cells in the thymus, but how it does so is not understood. In this study, we demonstrate that Ets1 is requ...ired for the proper termination of CD4 expression during the differentiation of major histocompatability class...
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Journal of Experimental Medicine
The first genetic resistance factor for tuberculosis (TB) infection is now reported by Cobat et al. The group has identified one locus that determines whether an individual will respond to the TB skin test and a second that controls the extent of that response. The results suggest that one major genetic locus controls ...innate resistance to the pathogen in humans.
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http://jem.rupress.org/cgi/content/full/
Read more at:
http://jem.rupress.org/cgi/content/full/
Journal of Experimental Medicine 's feed: Early Release Articles
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3
Infection by Toxoplasma gondii down-regulates the host innate immune responses, such as proinflammatory cytokine production, in a Stat3-dependent manner. A forward genetic approach recently de...monstrated that the type II strain fails to suppress immune responses because of a potential defect in a...
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Infection by Toxoplasma gondii down-regulates the host innate immune responses, such as proinflammatory cytokine production, in a Stat3-dependent manner. A forward genetic approach recently de...monstrated that the type II strain fails to suppress immune responses because of a potential defect in a...
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Journal of Experimental Medicine 's feed: Early Release Articles
Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-depe...ndent pathway and the generation of A/T mutations by the Msh2/ubiquitin...
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During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-depe...ndent pathway and the generation of A/T mutations by the Msh2/ubiquitin...
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Journal of Experimental Medicine
A lone amino acid change determines success or failure for strains of Toxoplasma gondii, say Yamamoto et al. The group identifies a kinase mutation that thwarts one strain's ability to activate Stat3 and halt the host immune response.
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http://jem.rupress.org/cgi/content/full/
Journal of Experimental Medicine
Stem cells stand a good chance of finding “parking spots” in bone marrow if they circulate long enough, report Bhattacharya et al. Hematopoietic stem cells frequently leave their niches, freeing up space for other stem cells to enter. If the factors coordinating this process can be better understood, induced vacancies ...could provide an alternative to radiation treatments and their accompanying side effects.
Read more at:
http://jem.rupress.org/cgi/content/full/
Read more at:
http://jem.rupress.org/cgi/content/full/
Journal of Experimental Medicine 's feed: Early Release Articles
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination
The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown mechanisms to suppress antigen receptor locus translocations during V(D...)J recombination. Formation of chromosomal coding joins and suppression of translocations invol...
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The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown mechanisms to suppress antigen receptor locus translocations during V(D...)J recombination. Formation of chromosomal coding joins and suppression of translocations invol...
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Salim “Slim” Abdool Karim joined the anti-apartheid movement as a boy in South Africa and has had the pleasure of watching the regime fall. Now he’s set his sights on taking down AIDS. Read more at: http://jem.rupress.org/cgi/content/full/206/11/2306
Saturday, October 24 (evening) A beetle larger than a baby's fist just scurried under the table before I could snap a photo. I’m at the table closest to the lawn, behind the tables of Maasai dancers sipping Kilimanjaro beer. ...
