Adobe Premiere

Have you reloaded Premiere software? Sounds like either a file is corrupted or too many temporary preview files might be choking your memory? If you're happy with what you have on the line and don't anticipate "undoing" some edits, you might consider deleting these temp files... That said, I'm no expert, but this is what I've experienced. I believe your memory "dump" is cleared out with rebooting... thus the reason the system will work for a while before filling again.

I will try the temp files. That does make sense. It does seem to happen when I have to use tons of photos. It did help when I shrunk the photos down to 1200 by X resolution.