K-State Division of Biology Mission Statement:
To generate and disseminate new and existing high-quality biological scientific knowledge, in a supportive and diverse environment, to students, professional colleagues, and the public through teaching,
To generate and disseminate new and existing high-quality biological scientific knowledge, in a supportive and diverse environment, to students, professional colleagues, and the public through teaching,
Information
- Location:
- Manhattan, KS, 66506
- Phone:
- (785) 532-6615
- Mon - Fri:
- 8:00 am - 12:00 pm
1:00 pm - 5:00 pm
Events
5 past eventsSee All
- Marjorie D. Matocq, Associate ...
221 Ackert Hall
Friday, November 20 at 4:00pm - Don Feener from the University...
Ackert Hall, Room 221
Friday, November 6 at 4:00pm - Mizuki Azuma, University of Ka...
221 Ackert Hall
Friday, October 30 at 4:00pm - Dr. George Dimopoulos - Seminar
Waters Hall, Room 137
Friday, October 30 at 1:30pm - Punidan Jeyasingh from Oklahom...
KSU- Ackert 221
Friday, October 23 at 4:00pm
Division of Biology at Kansas State University
Title: Evolutionary diversification of Neotoma: the roles of ecology, behavior, and morphology at species boundaries.
Projects in our lab focus on studying patterns of geographic population genetic structure and the processes underlying such patterns. Because the current geographic distribution of genetic diversity is d...etermined by a complex interplay of ecology, demography, and population history, our studies are performed at various spatial and temporal scales. To study the processes underlying patterns of genetic diversity and subdivision, we combine modern molecular genetic techniques with morphological and field studies.
Division of Biology Seminar Series
Time:4:00PM Friday, November 20th
Location:221 Ackert Hall
Division of Biology at Kansas State University
Dr. George Dimopoulos
Department of Molecular Microbiology and Immunology at the Malaria ResearchInstitute
Bloomberg School of Public Health, Johns Hopkins University
Host: Marcelo Ortigao, Department of Entomology
Co-sponsored by: Department of Entomology
Title: "The mosquito microbiota in the defenses against human patho...gens"
Abstract: Malaria transmitting mosquitoes are continuously exposed to
microbes, including their midgut microbiota. This naturally acquired
microbial flora can modulate the mosquito's vectorial capacity by inhibiting
the development of Plasmodium and other human pathogens through an unknown
mechanism. We have undertaken a comprehensive functional genomic approach to
elucidate the molecular interplay between the bacterial co-infection and the
development of the human malaria parasite Plasmodium falciparum in its
natural vector Anopheles gambiae. Global transcription profiling of septic
and aseptic mosquitoes identified a significant subset of immune genes that
were mostly up-regulated by the mosquito's microbial flora, including
several anti-Plasmodium factors. Microbe-free aseptic mosquitoes displayed
an increased susceptibility to Plasmodium infection while co-feeding
mosquitoes with bacteria and P. falciparum gametocytes resulted in lower
than normal infection levels. Infection analyses suggest the
bacteria-mediated anti-Plasmodium effect is mediated by the mosquitoes'
antimicrobial immune responses, plausibly through activation of basal
immunity. We show that the microbiota can modulate the anti-Plasmodium
effects of some immune genes. We have characterized the microbiota of
malaria vectors in the field and identified bacteria species that have the
capacity to render the mosquito completely resistant to Plasmodium
infection. In sum, the microbiota plays an essential role in modulating the
mosquito's capacity to sustain Plasmodium infection.
Additional information:
Faculty Page: <http://faculty.jhsph.edu/?F=George&L=Dim
http://faculty.jhsph.edu/?F=George&L=Dim
Group Page: <http://www.dimopoulosgroup.org/>
http://www.dimopoulosgroup.org/
Time:1:30PM Friday, October 30th
Location:Waters Hall, Room 137
Division of Biology at Kansas State University
We have two positions open for Assistant Professor - Pathogen-Host Interactions and Assistant Professor - Bacterial Pathogenesis Microbiology or Host-Bacterial Interactions. For more information about all our job openings visit http://www.ksu.edu/biology/employment.ht
www.ksu.edu
Division of Biology at Kansas State University K-STATE'S DIVISION OF BIOLOGY RECEIVES MORE THAN $780,000 FROM U.S. DEPARTMENT OF EDUCATION TO FUND GRADUATE STUDENTS (To read more see the whole release on our discussions tab)
Division of Biology at Kansas State University
FYI ** The submission deadline for Commerce Bank Award nominations is
OCTOBER 23, 5:00 p.m. **
http://www.k-state.edu/ddcd/CommerceBank
http://www.k-state.edu/ddcd/CommerceBank
www.k-state.edu
Division of Biology at Kansas State University
TITLE: Ewing sarcoma fusion protein EWS/FLI1 interacts with EWS leading to mitotic defects in zebrafish embryos and human cell lines
Ewing sarcoma is the second most common form of bone cancer in children and young adults. The t(11;22) chromosomal translocation results in expression of a chimeric fusion protein containi...ng EWS-derived sequences at the amino-terminal region and carboxy-terminal regions of the ETS transcription factor FLI1. The mechanism whereby the fusion of EWS with the ETS transcription factor FLI1 contributes to malignant transformation in Ewing sarcoma remains unclear. We demonstrate that injection of human or zebrafish EWS/FLI1 mRNA into developing zebrafish embryos leads to mitotic defects with multipolar and disorganized mitotic spindles. Expression of human EWS/FLI1 in HeLa cells also results in mitotic defects, along with mislocalization of Aurora kinase B, a key regulator of mitotic progression. Since these mitotic abnormalities mimic those observed with knockdown of EWS in zebrafish embryos and HeLa cells, we investigated whether EWS/FLI1 interacts with EWS and interferes with its function. EWS co-immunoprecipitates with EWS/FLI1, and overexpression of EWS rescues the mitotic defects in EWS/FLI1-transfected HeLa cells. This interaction between EWS/FLI1 and EWS in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
If you would like to meet with Dr. Azuma, contact Dr. Katsura Asano at kasano@ksu.edu or
2-0116.
Division of Biology Seminar Series
Time:4:00PM Friday, October 30th
Location:221 Ackert Hall
Division of Biology at Kansas State University
Title: Using chemical elements to understand genotypic and phenotypic variation
It is clear that availability of elements vary in space and time. The supply of limiting elements should be a strong selective force driving the evolution of traits depending on the elemental cost involved in its expression. Experiments mani...pulating the supply of limiting elements to freshwater crustaceans impacts gene regulation, and allocation to organs or functions. Moreover, strong G x E interactions were observed in fitness-relevant traits. Identifying proximate mechanisms underlying such effects is of essence to understand the environmental role in the origin of heritable variation. Furthermore, understanding the elemental cost associated with the expression of a phenotype will enable us to predict its variation using data on the elemental supply conditions in the ecosystem inhabited by the study organism.
If you would like to meet with Dr. Jeyasingh, contact Dr. Keith Gido at 2-5088 or kgido@ksu.edu.
