This Resource is supported by the National Institutes of Health (NIH) through a National Center for Research Resources program grant (P 41 RR08605) to researchers at the University of California, San Diego and other member Institutions.
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- Founded:
- May 1, 1994
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Events
5 past eventsSee All
- NBCR CSSS 2010
Fung Auditorium, PFBH Hall, UCSD
Thursday, March 11 at 4:00pm - Resource Centers of NCRR, an e...
Moscone Center, Booth #329, San Fra...
Sunday, February 21 at 10:00am - NBCR RAC Meeting
Monday, February 8 at 8:15am - Modeling and simulation of act...
Fung Auditorium, PFBH Hall, UCSD
Tuesday, January 12 at 4:00pm - NBCR PI's Meeting
Atkinson Hall, Room 5004
Thursday, December 17 at 1:00pm
National Biomedical Computation Resource (NBCR) The 2010 Biophysical Society Annual Meeting at the Moscone Convention Center, San Francisco, CA
Time:10:00AM Sunday, February 21st
Location:Moscone Center, Booth #329, San Francisco, BPS 2010
National Biomedical Computation Resource (NBCR) NBCR Advisory Committee
Time:8:15AM Monday, February 8th
National Biomedical Computation Resource (NBCR)
Dynamical View of Energy Coupling Mechanisms in Active Membrane Transporters
Emad Tajkhorshid, PhD
Department of Biochemistry, Center for Biophysics and Computational Biology, and Beckman Institute, University of Illinois at Urbana Champaign
Membrane transporters constitute the principal players in active exchange of mat...erials across the cellular membrane in an energy-dependent manner. These complex proteins constitute highly sophisticated, fine-tuned molecular pumps that efficiently couple various sources of energy in the cell to the transport of a wide range of molecules across the membrane against their chemical gradient. Substrate binding and translocation along the transport pathway in membrane transporters are closely coupled to numerous stepwise protein conformational changes of various magnitudes that are induced by and/or coordinated with the energy-providing mechanisms. A detailed description of the mechanism of membrane transporters, therefore, relies on high-resolution methodologies that can describe the dynamics of the process at an atomic level. In this talk, latest results of molecular dynamics simulations performed on a number of atomic structures of membrane transporters and the molecular events involved in their function revealed by these simulations will be presented.
Dynamical View of Energy Coupling Mechanisms in Active Membrane Transporters
Time:4:00PM Thursday, March 11th
Location:Fung Auditorium, PFBH Hall, UCSD
National Biomedical Computation Resource (NBCR)
Title: Modeling and simulation of actin polymerization in cells.
Speaker: Leslie M. Loew, Ph.D.
Abstract: We have built a quantitative model based on the dendritic nucleation scheme for actin assembly. The model explicitly incorporates the major mechanisms for actin polymerization starting with activation of Arp2/3 at th...e cell membrane by NWASP. We first used this model to establish the steady state properties of the actin system in the absence of nucleation by Arp2/3. The model reproduces all the experimental behaviors derived from in vitro studies of sub-systems of the component molecules. We then constructed 3D spatial models of cells with thin lamellipodia and thick cell bodies. Activation of Arp2/3 in a small segment of lamellipodium membrane causes rapid localized actin nucleation and a buildup of F-actin to the 1mM level. The model provides an explanation for speckle microscopy experiments showing a remarkably sharp transition from filament assembly at the leading edge of cells and filament disassembly just 1µm away from the leading edge. We also applied the model to experimental data on signaling aggregates propelled by actin comet tails. Simulation results are in quantitative agreement with the observed profiles of actin distribution in the comets. Because this model and the simulation results are "open source", in the sense that they are publicly available and editable through the Virtual Cell database (http://vcell.org), they can be accessed, analyzed, modified and extended.
Bio: Leslie M. Loew is Professor of Cell Biology, Director of the Richard D. Berlin Center for Cell Analysis and Modeling (CCAM) and holds the Boehringer Ingelheim Chair in Cell Sciences at the University of Connecticut Health Center. He is also Professor of Computer Science and Engineering within the School of Engineering on the UCONN Storrs campus. Loew came to Farmington in 1984 after 10 years on the faculty of SUNY at Binghamton in the Department of Chemistry. He received his Ph.D. in Chemistry from Cornell University and was a post-doctoral fellow in the laboratory of F. H. Westheimer at Harvard University. His research focuses on the chemical and physical mechanisms underlying cell biological processes. As a key part of this research he has been involved in the design and synthesis of fluorescent dyes to probe cell physiology and the development of quantitative high resolution microscopic methods for mapping cell structure and function. His laboratory is credited with being the first to apply the non-linear optical effect known as second harmonic generation to high resolution microscope imaging. He established CCAM in 1994 with the aim of developing new optical, photonic, image processing and computational techniques for the investigation of the behavior of living cells. The largest CCAM project, Virtual Cell, aims to develop a computational environment for modeling the complex events underlying cell function. It is the core technology development project of a NIH/NCRR “National Biomedical Technology Research Resource” and has over 12,000 registered users worldwide. Most recently, the computational and biophotonics research that is housed within CCAM has led to the establishment of a “National Technology Center for Networks and Pathways” at UCHC with a $12.3M five year NIH Roadmap grant, of which Loew is the Principal Investigator. CCAM has also become a regional resource for the biomedical research community with over $7 million of state of the art instrumentation used by approximately 50 academic and industrial laboratories. Loew is the author of over 150 research publications, including 3 patents and 1 book; he lectures widely, traveling to scientific meetings and universities about once each month to deliver invited seminars. Over 40 Ph.D. and post-doctoral students have need trained in Loew’s laboratory. He is the founding and continuing organizer of the international symposium on Computational Cell Biology, is on several Editorial Boards for scientific journals and has served as Chair of the Modeling and Analysis of Biological Systems NIH Study Section.
Time:4:00PM Tuesday, January 12th
Location:Fung Auditorium, PFBH Hall, UCSD
National Biomedical Computation Resource (NBCR) NBCR PI's meeting
Time:1:00PM Thursday, December 17th
Location:Atkinson Hall, Room 5004
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National Biomedical Computation Resource (NBCR) NBCR Tech Mini Series
Location:Atkinson Hall, Room 2004
Time:10:00AM Thursday, December 17th
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