TPAC is located in the James K. Polk Cultural Center at 505 Deaderick Street in downtown Nashville, occupying an entire city block between 5th and 6th Avenues and Deaderick and Union Streets.The performance venues at TPAC are Andrew Jackson Hall (2,472 seats), James K. Polk Theater (1,075), Andrew Johnson Theater (256) and War Memorial Auditorium (1,661), the historic landmark located across 6th Avenue and the plaza from the Center.

The mission of the Tennessee Performing Arts Center is "to provide facilities, services and programs of the highest quality for the greatest benefit of the people, institutions and communities of the state, and to take a leadership role in fostering the performing arts, arts education, resident arts groups and other arts organizations."

Broadway plays and musicals, Resident Companies (Nashville Ballet, Nashville Opera, Tennessee Repertory Theatre), and other live music and theatric events.