ALIUSCollege & University in Paris, France
We are very proud to announce the launch of issue #2 of the ALIUS Bulletin, featuring in-depth interviews with Kieran Fox, Karl Friston, Thomas Metzinger, David Nichols, Kevin O'Regan, Matthew Ratcliffe & Ann Taves! This is our biggest issue yet.
It is available in open access on our website: https://www.aliusresearch.org/bulletin02.html
Many thanks to the interviewers – Matthieu Koroma, Martin Fortier, Daniel Friedman, Jakub Limanowski, Raphaël Millière, Christopher Timmermann, Leor Roseman, Cordelia Erickson-Davis, Mathieu Frerejouan & Maddalena Canna!
The philosophy of the self, with Evan Thompson
"These findings are consistent with a predictive coding account of hallucinations in schizophrenia, which posits reduced prediction error signaling in those who are prone to hallucinations. These results also suggest that plasticity-mediated formation and online updating of predictive coding models may also be disrupted in individuals with recent hallucinations."
Prediction of activation patterns preceding hallucinations in patients with schizophrenia using machine learning with structured sparsity
“ This article first proposes a machine-learning algorithm to automatically identify resting-state fMRI periods that precede hallucinations versus periods that do not. […] we obtained reliable classifying performances associated with interpretable predictive patterns, composed of two clearly identifiable clusters in speech-related brain regions. “
Fake ‘God Helmet’ can elicit extraordinary experiences. On this topic, see also Michiel van Elk's talk at the ALIUS workshop: https://vimeo.com/248878678
Recent interesting piece on cognitive penetrability
"the influence of awe upon the small self accounted for increases in collective engagement, fitting with claims that awe promotes integration into social groups"
Renaud Jardri on the neuroscience of schizophrenic hallucinations at the ALIUS Workshop last December
Gallagher on enactivism and consciousness: "This analysis shows that the enactive character of intentionality
in general, goes all the way down; it is embedded in the micro-structure of time-consciousness, and this
has implications for understanding perception and action. This account is consistent with Varela’s constructivist approach to cognition."
"Here, we examined 5-MeO-DMT effects on oscillatory activity in prefrontal (PFC) and visual (V1) cortices, and in mediodorsal thalamus (MD) of freely-moving wild-type (WT) and 5-HT2A-R knockout (KO2A) mice. We performed local field potential multi-recordings evaluating the power at different frequency bands and coherence between areas. We also examined the prevention of 5-MeO-DMT effects by the 5-HT1A-R antagonist WAY-100635.
5-MeO-DMT affected oscillatory activity more in co...rtical than in thalamic areas. More marked effects were observed in delta power in V1 of KO2A mice. 5-MeO-DMT increased beta band coherence between all examined areas. In KO2A mice, WAY100635 prevented most of 5-MeO-DMT effects on oscillatory activity.
The present results indicate that hallucinatory activity of 5-MeO-DMT is likely mediated by simultaneous alteration of prefrontal and visual activities. The prevention of these effects by WAY-100635 in KO2A mice supports the potential usefulness of 5-HT1A receptor antagonists to treat visual hallucinations. 5-MeO-DMT effects on PFC theta activity and cortico-thalamic coherence may be related to its antidepressant activity."