ראה/ראי עוד מ-‏‎ALIUS‎‏ על ידי התחברות לפייסבוק
שלח/י הודעה לדף זה כדי לקבל מידע נוסף על אירועים ועוד.
ראה/ראי עוד מ-‏‎ALIUS‎‏ על ידי התחברות לפייסבוק
שלח/י הודעה לדף זה כדי לקבל מידע נוסף על אירועים ועוד.
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ביקורות
‏5‏ ביקורות
ספר/י לאנשים מה את/ה חושב/ת
פוסטים

It is with great pleasure that we would like to announce the launch of the ALIUS Bulletin, a new annual publication edited by Martin Fortier, François Lemoine and Raphaël Millière.

The Bulletin contains interviews with prominent researchers working on consciousness and its altered states across many disciplines. This first issue includes interviews with Robin Carhart-Harris, Jakob Hohwy, Tanya Luhrmann, Simon McCarthy-Jones, Rebecca Seligman and Jennifer Windt.

Read it now: ...http://www.aliusresearch.org/bulletin.html

And share the news!

הצג עוד
The ALIUS Bulletin is an annual publication featuring in-depth interviews with prominent scholars working on consciousness and its altered states (ASCs). The goal of the Bulletin is to present a...
aliusresearch.org

The video recording of Leor Roseman's talk at Psychedelic Science 2017 is now available online.
"fMRI was measured before and after psilocybin-assisted therapy for treatment resistant depression (n=20) and changes in the amygdala were recorded in response to emotional stimuli. Amygdala reactivity to emotional faces (positive and negative) increased 1-day after psilocybin-assisted therapy. This is opposite to amygdala changes induced by chronic administration of anti-depressan...ts (reduced reactivity to negative faces). This discrepancy may be related to fundamental differences in these two approaches: with anti-depressants working to mitigate negative emotions and psychedelic-assisted therapy working to confront and work through them. Patients in this study showed a rapid alleviation of symptoms, suggesting that attenuated amygdala responsiveness may not be necessary for therapeutic efficacy. Psychedelic therapy may provide a treatment avenue that preserves, and potentially remediates emotional responsiveness in depression.
Furthermore, our study revealed that strong peak-experience and low anxiety during the psilocybin session, predicted a positive clinical outcome, while the strength of the visual imagery did not. This result strengthen the theoretical framework that peak/mystical/transcendental experience mediates positive changes. Moreover, this result emphasis the importance of the set and setting, and the importance of the preparation. This result will be discussed in relation to Maslow’s peak experience theory and possible neural mechanism that relate to the acute experience and the long term changes."

הצג עוד
Learn more and donate: http://www.maps.org/ Leor Roseman, MSc Psilocybin-Assisted Therapy: Neural Changes and the Relationship Between the Acute Peak Experie...
youtube.com
‎פוסטים‎

More data on potential long-term effects of psychedelic use on personality traits and beliefs. Lifetime psychedelic use (and specifically ego dissolution) linked to liberal political views, openness and nature relatedness. New paper by our very own Matthew Nour, co-authored with Lisa Evans and Robin Carhart-Harris.

(2017). Psychedelics, Personality and Political Perspectives. Journal of Psychoactive Drugs. Ahead of Print. doi: 10.1080/02791072.2017.1312643
tandfonline.com

A short general audience piece proposing a predictive coding account of psychedelic hallucinations.

Psychiatrists usually define hallucination as a sensory experience that appears to be real, but is not produced by any actual object of the environment...
chacruna.net
‏‎ALIUS‎‏ הוסיף/הוסיפה ‏‏4‏ תמונות חדשות‏ מ-‏אפריל‏ לאלבום: ‏‎ALIUS Workshop on Hallucinogenic experiences @ Stanford‎‏ — עם ‏‎Leor Roseman‎‏ ו-‏‏5‏ נוספים‏ ב‏‏‏‏‎Stanford University‎‏‏.
אפריל
התמונה של ‏‎ALIUS‎‏.
התמונה של ‏‎ALIUS‎‏.
התמונה של ‏‎ALIUS‎‏.
התמונה של ‏‎ALIUS‎‏.
‏‎ALIUS‎‏ שיתף/שיתפה ‏קישור‏.
What is the level of consciousness of the psychedelic state? Empirically, measures of neural signal diversity such as entropy and Lempel-Ziv (LZ) complexity score higher for wakeful rest than for states with lower conscious level like propofol-induced anesthesia.
nature.com

A predictive coding look at religious experience

(2017). How does religious experience work in predictive minds?. Religion, Brain & Behavior. Ahead of Print. doi: 10.1080/2153599X.2016.1249913
tandfonline.com

Most recent paper by Phil Corlett summarizing evidence in favor of the prediction deficit model of ketamine and schizophrenia

To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect.
biologicalpsychiatryjournal.com

The MIND Group has just published its second collection of open-access papers, after Open Mind: "Philosophy and Predictive Processing" edited by Thomas Metzinger and Wanja Wiese.

Presentation

"Predictive processing is at the cutting edge of theoretical cognitive science, and its philosophical implications are currently being hotly debated. However, philosophical newcomers to the debate can easily be deterred by the copious technical details, and given the pace of developments..., it can be a struggle to stay up-to-date. As a primarily philosophical project, the main goal of this initiative is to offer a first introduction to the debate on predictive processing and to begin a more systematic discussion from a conceptual and metatheoretical perspective. In this second collection from the MIND Group, the number of invited authors is much smaller than for our first collection, and the papers have a narrower thematic focus in the philosophy of cognitive science, deliberately picking out only one topic of especially high relevance and urgency. We want to provide a service to the community by offering a concerted voice and a brief introduction for non-specialists.

Continuing the spirit of the Open MIND-project we also wanted to make our academic work available independently of a publisher who would eventually sell our own intellectual property back to us and our peers while simultaneously locking it behind a pay wall, making it inaccessible to students in countries such as Brazil, India and China. Once again, we have achieved a professional form of quality control via a systematic, two-layered, but journal-independent peer-review process — and we have released the results faster than would existing and established institutions of academic publishing. We hope you find the electronic resource we have created helpful for your own research."

הצג עוד

"Philosophies of anxiety"
Great topic and great line-up (Shaun Gallagher and Matthew Ratcliffe among others)

PHILOSOPHIES OF ANXIETY Brexit. Trump. Terrorism. The rise of the far-right. Anxiety is both everywhere and nowhere at once. At once a condition to be understood in psychiatric and psychoanalytical terms, anxiety is also a political, aesthetic, cultural, and metaphysical affair. To what extent is an...
eventbrite.ie

Abstract

Hallucinogens evoke sensory, perceptual, affective, and cognitive effects that may be useful to understand the neurobiological basis of mood and psychotic disorders. The present chapter reviews preclinical research carried out in recent years in order to better understand the action of psychotomimetic agents such as the noncompetitive NMDA receptor (NMDA-R) antagonists and serotonergic hallucinogens. Our studies have focused on the mechanisms through which these agen...ts alter cortical activity. Noncompetitive NMDA-R antagonists, such as phencyclidine (PCP) and MK-801 (dizocilpine), as well as the serotonergic hallucinogens DOI and 5-MeO-DMT, produce similar effects on cellular and population activity in prefrontal cortex (PFC); these effects include alterations of pyramidal neuron discharge (with an overall increase in firing), as well as a marked attenuation of the low frequency oscillations (0.2–4 Hz) to which neuronal discharge is coupled in anesthetized rodents. PCP increases c-fos expression in excitatory neurons from various cortical and subcortical areas, particularly the thalamus. This effect of PCP involves the preferential blockade of NMDA-R on GABAergic neurons of the reticular nucleus of the thalamus, which provides feedforward inhibition to the rest of thalamic nuclei. It is still unknown whether serotonergic hallucinogens also affect thalamocortical networks. However, when examined, similar alterations in other cortical areas, such as the primary visual cortex (V1), have been observed, suggesting that these agents affect cortical activity in sensory and associative areas. Interestingly, the disruption of PFC activity induced by PCP, DOI and 5-MeO-DMT is reversed by classical and atypical antipsychotic drugs. This effect suggests a possible link between the mechanisms underlying the disruption of perception by multiple classes of hallucinogenic agents and the therapeutic efficacy of antipsychotic agents.

Keywords
5-HT2A receptors Antipsychotic drugs NMDA receptors Prefrontal cortex Thalamus

הצג עוד
Hallucinogens evoke sensory, perceptual, affective, and cognitive effects that may be useful to understand the neurobiological basis of mood and psychotic disorders. The present chapter reviews preclinical research carried out in recent years in order to better understand the action of psychotomimet...
link.springer.com
‏‎ALIUS‎‏ שיתף/שיתפה ‏קישור‏.
The ALIUS Bulletin is an annual publication of the ALIUS research group, featuring in-depth interviews with prominent scholars working on consciousness and its altered states (ASCs). The goal of th…
philosophyofbrains.com

R. Guevara Erra, D. M. Mateos, R. Wennberg & J.L. Perez Velazquez (2017), "Towards a statistical mechanics of consciousness: maximization of number of connections is associated with conscious awareness"

Abstract

It has been said that complexity lies between order and disorder. In the case of brain activity, and physiology in general, complexity issues are being considered with increased emphasis. We sought to identify features of brain organization that are optimal for sensor...y processing, and that may guide the emergence of cognition and consciousness, by analysing neurophysiological recordings in conscious and unconscious states. We find a surprisingly simple result: normal wakeful states are characterised by the greatest number of possible configurations of interactions between brain networks, representing highest entropy values. Therefore, the information content is larger in the network associated to conscious states, suggesting that consciousness could be the result of an optimization of information processing. These findings encapsulate three main current theories of cognition, as discussed in the text, and more specifically the conceptualization of consciousness in terms of brain complexity. We hope our study represents the preliminary attempt at finding organising principles of brain function that will help to guide in a more formal sense inquiry into how consciousness arises from the organization of matter.

הצג עוד

Jardri et al. Nature Communications 2017 "Experimental evidence for circular inference in schizophrenia"

Abstract: Schizophrenia (SCZ) is a complex mental disorder that may result in some combination of hallucinations, delusions and disorganized thinking. Here SCZ patients and healthy controls (CTLs) report their level of confidence on a forced-choice task that manipulated the strength of sensory evidence and prior information. Neither group’s responses can be explained by si...mple Bayesian inference. Rather, individual responses are best captured by a model with different degrees of circular inference. Circular inference refers to a corruption of sensory data by prior information and vice versa, leading us to ‘see what we expect’ (through descending loops), to ‘expect what we see’ (through ascending loops) or both. Ascending loops are stronger for SCZ than CTLs and correlate with the severity of positive symptoms. Descending loops correlate with the severity of negative symptoms. Both loops correlate with disorganized symptoms. The findings suggest that circular inference might mediate the clinical manifestations of SCZ.

הצג עוד
Schizophrenia is a mental disorder characterized by hallucinations and delusions. Here the authors report a novel probabilistic inference task in which compared to healthy subjects, schizophrenia patients show greater degree of circular inference that matches the severity of their clinical symptoms.
www.nature.com

*Recent paper: "Crystal Structure of an LSD-Bound Human Serotonin Receptor" (http://www.cell.com/cell/abstract/S0092-8674(16)31749-4…)
*And recent general-audience interview about/around this paper: "Is It a Myth That LSD Can Permanently Fry Your Brain" (https://www.vice.com/…/is-it-a-myth-that-lsd-can-permanentl…)

The structure of LSD with a serotonin receptor reveals the basis for its long-lasting effects and suggests ways to selectively alter receptor signaling.
cell.com

Braboszcz et al. "Increased Gamma Brainwave Amplitude Compared to Control in Three Different Meditation Traditions" [PLoS ONE]

"Despite decades of research, effects of different types of meditation on electroencephalographic (EEG) activity are still being defined. We compared practitioners of three different meditation traditions (Vipassana, Himalayan Yoga and Isha Shoonya) with a control group during a meditative and instructed mind-wandering (IMW) block. All meditators show...ed higher parieto-occipital 60–110 Hz gamma amplitude than control subjects as a trait effect observed during meditation and when considering meditation and IMW periods together. Moreover, this gamma power was positively correlated with participants meditation experience. Independent component analysis was used to show that gamma activity did not originate in eye or muscle artifacts. In addition, we observed higher 7–11 Hz alpha activity in the Vipassana group compared to all the other groups during both meditation and instructed mind wandering and lower 10–11 Hz activity in the Himalayan yoga group during meditation only. We showed that meditation practice is correlated to changes in the EEG gamma frequency range that are common to a variety of meditation practices."

הצג עוד
Despite decades of research, effects of different types of meditation on electroencephalographic (EEG) activity are still being defined. We compared practitioners of three different meditation traditions (Vipassana, Himalayan Yoga and Isha Shoonya) with a control group during a meditative and instru...
journals.plos.org