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Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195
medscimonit.com
Aberrant expression of lncRNA has been suggested to have an association with tumorigenesis. Our study was designed to reveal the underlying connection between lncRNA SNHG1 and hepatocellular carcinoma (HCC) pathogenesis.<br />
lncRNA SNHG1 may contribute to the aggravation of HCC through the inhibit...
Aberrant activation of the Wnt/β-catenin has shown to promote ovarian cancer proliferation and chemoresistance. A FDA-approved anthelmintic drug pyrvinium has been identified as a potent Wnt inhibitor. Pyrvinium may sensitize ovarian cancer cells to chemotherapy. <br />
In this study, we demonstrated that the anthelmintic drug pyrvinium targets ovarian cancer cells through suppressing Wnt/β-catenin signalling. Our work highlighted the therapeutic value of Wnt/ β-catenin in ovarian cancer.
medscimonit.com
Aberrant activation of the Wnt/β-catenin has shown to promote ovarian cancer proliferation and chemoresistance. A FDA-approved anthelmintic drug pyrvinium has been identified as a potent Wnt inhibitor. Pyrvinium may sensitize ovarian cancer cells to chemotherapy. <br />
In this study, we demonstrate...
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