Rotello's Lab work on 22 News

Moumita Ray graduated from the group. Many many congratulations to you. Thanks for all the contributions and best of luck for your future journey!!

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Ryan Landis, a graduate student in the Rotello group, was awarded $20,000 in seed money for the company he founded, Phytos Therapeutics, in the finals of the Innovation Challenge, a campus-wide entrepreneurial competition.
Congratulations Ryan for your achievement!!!

Innovation Challenge: The Final (4/5/18)

The number of bacteria that are gaining resistance to traditional antibiotics is rapidly increasing. Join Prof. Vince M. Rotello for a look at how nanomaterials provide an ‘outside the box’ alternative that shows considerable promise against these rapidly emerging pathogens. This new area of research is perhaps the most promising strategy to averting the health crisis threatened by antibiotic-resistant bacteria.

Recently, Dr. Juan Qiao finished her visit in the group. Wish you good luck for your future and thanks for all the contributions!!

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The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes. In this review, Scaletti et al. discuss recently developed inorganic nanoparticle-protein supramolecular assemblies for protein delivery. Challenges in the field, particularly achieving effective cytosolic protein delivery through endosomal escape or evasion are discussed.…/co…/articlelanding/2018/cs/c8cs00008e…

The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes, including cancer therapy, immunomodulation and treatment of inherited diseases. In this review, we present recently developed nanoassemblies for protein delivery that utilize strategies that ran...

Dr. Dongyu Zhu finished her visit in the group. It was great to work with you. Thanks a lot for all the contributions and wish you good luck for your future!!

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Hello, everyone!! If you want to meet with Prof. Rotello, he will be participating in ACS on Campus India Roadshow events at University of Delhi (, IIT Roorkee ( and IISER Mohali (

Registration is FREE! Network, promote your science (at one of the poster sessions) and hear great talks about research and publication!

What can be better building block for developing biomaterials than naturally abundant proteins? Imparting proteins molecular properties to materials surface is, however, challenging due to loss of protein structure upon film formation. In this work, Wang et. al. developed an additive-free and versatile method to fabricate functional protein coatings that retains protein charge, secondary structure, biodegradability and hydrophilicity.

Most of the transition metals catalysts (TMCs) lacks the solubility, stability, and activity in aqueous environment. This work by Jeong. et. al. describes a modular strategy to solubilize and stabilize different hydrophobic TMCs through the encapsulation of the catalysts into the monolayer of water-soluble gold nanoparticles. Beside bringing water solubility and providing a protecting environment for the catalyst, this platform is reusable without any lost in catalytic activity.

In this work the gold nanoparticle-CRISPR/Cas9 machinery is used to knock out the "don't eat me signal" in macrophages, allowing phagocytosis of cancer cells. Check out the paper by Ray. et. al. to know more about this integrated nanotechnology/biology approach to create 'weaponized' macrophages for cancer immunotherapy.

CRISPRed Macrophages for Cell-Based Cancer Immunotherapy

Jessa Marie Makabenta and Rui Huang joined the group as graduate students in this year. Congrats to both of you!!

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We all know that the structure of different biomaterials plays an important role in the activity. The functionality of these biological systems, such as, proteins, cell/bacterial membranes
are involved in many biological problems as well. In this article, Tullius. et. al. reports fingerprinting of Protein Interface Structure.

Superchiral Plasmonic Phase Sensitivity for Fingerprinting of Protein Interface Structure

"There is no sincerer love than the love of food" - George Bernard Shaw. So, here are the pictures of Potluck 2017!!

Rotello group has developed a general strategy to image bio-films that can rapidly "light-up" the infected mammalian cells. In this work, Gupta. et. al. fabricate NP-based systems that are stimulated by the altered micro-environment of bio-films.

Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections